HORDB

ID: hor002887
Uniprot ID: P17219
Protein name: P6K
Gene name: NA
Organism: Bombyx mori (Silk moth)
Family: NA
Source: animal
Expression: PTTH is synthesized by two dorsolateral neurosecretory cells of the Bombyx brain.
Disease: NA
Comments: NA
Taxonomy: Bombyx (genus), Bombycinae (subfamily), Bombycidae (family), Bombycoidea (superfamily), Obtectomera, Ditrysia, Heteroneura (parvorder), Neolepidoptera (infraorder), Glossata (suborder), Lepidoptera (order), Amphiesmenoptera (superorder), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: NA

Sequence: ARNDVLGDKENVRPNPYYTEPFDPDTSPEELSALIVDYANMIRNDVILLDNSVETRT
Length: 57(56-112)
Propeptide: MITRPIILVILCYAILMIVQSFVPKAVALKRKPDVGGFMVEDQRTHKSHNYMMKRARNDVLGDKENVRPNPYYTEPFDPDTSPEELSALIVDYANMIRNDVILLDNSVETRTRKRGNIQVENQAIPDPPCTCKYKKEIEDLGENSVPRFIETRNCNKTQQPTCRPPYICKESLYSITILKRRETKSQESLEIPNELKYRWVAESHPVSVACLCTRDYQLRYNNN
Signal peptide: MITRPIILVILCYAILMIVQSFVPKAVAL
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: PTTH is a brain secretory polypeptide of insects which stimulates the prothoracic glands to produce and release ecdysone, the steroid essential to insect development.; Peptides P2K and P6K are presumed to be cleaved post-translationally and may play some
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-O00230-F1.pdb

hor002887_AF2.pdb

hor002887_ESM.pdb

Mass:	749616	Formula:	C282H442N76O98S
Absent amino acids:	CHQW	Common amino acids:	DN
pI:	3.89	Basic residues:	5
Polar residues:	17	Hydrophobic residues:	17
Hydrophobicity:	-68.07	Boman Index:	-14980
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	85.44
Instability Index:	4428.25	Extinction Coefficient cystines:	4470
Absorbance 280nm:	79.82